Summary of GlycoTech's Selectin Assays
Assays used to discovery unique selectin antagonists
Ligand Binding Assays for E- and P-selectin
Inhibition assay using native carbohydrate structures as the target. IC50 values are similar to KD
Fluorescence Shift Binding Assays for E- and P-selectin
Direct binding assay that determines a physical constant (KD).
Highly Sensitive P-selectin Inhibition Assay
Inhibition assay using synthetic polymers of ligands as the target. This assay is
highly sensitive and detects slight activities (low IC50
Static Cell Adhesion Assay for P-selectin
A highly reproducible assay that measures the inhibition of P-selectin mediated cell
adhesion in a microtiter plate format.
Cell Adhesion Flow Assays for E- and P-selectin
State-of-the-art assays that measures the different stages of cell adhesion under
hydrodynamic flow conditions by real time digital image analysis.