CD36 (Platelet & Microvessel Marker)(1A7) , Biotin conjugate , 0.1mg / mL

This antibody recognizes a protein of 80-90 kDa , identified as CD36. It is expressed on platelets , monocytes and macrophages , microvascular endothelial cells , erythrocyte precursors , mammary epithelial cells , and some macrophage derived dendritic cells. CD36 acts as a receptor for thrombospondin (TSP) , collagen types I , IV and V , P. falciparum malaria-infected erythrocytes , and sickle erythrocytes. It also functions as a scavenger receptor , mediating macrophage uptake of oxidized low-density lipoprotein (LDL) and recognition of apoptotic polymorphonuclear leukocytes (PMN). CD36 plays a role in platelet aggregation , macrophage foam cell development , inflammation , and the tissue ischemia observed in sickle cell disease and cerebral malaria. Note that 1-4% of Japanese and East Asia population lack CD36.