Pmel17 / gp100 / SILV(HMB45) , Biotin conjugate , 0.1mg / mL

By immunohistochemistry , this antibody specifically recognizes a protein in melanocytes and melanomas. It reacts with junctional and blue nevus cells and variably with fetal and neonatal melanocytes. Intradermal nevi , normal adult melanocytes , and non-melanocytic cells are negative. It does not stain tumor cells of epithelial , lymphoid , glial , or mesenchymal origin. Metastatic amelanotic melanoma can often be confused with a variety of poorly differentiated carcinomas , large cell lymphomas , and sarcomas using H & E stains alone. It is also difficult to differentiate melanoma from spindle cell carcinomas and various types of mesenchymal neoplasms. This MAb stains fetal and neonatal melanocytes , junctional and blue nevus cells , malignant melanoma , and angiomyolipoma (PEComa).Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.