CD13(APN/514) , Biotin conjugate , 0.1mg / mL

This MAb recognizes an extracellular epitope of an integral membrane glycoprotein of 150 kDa , identified as CD13. This antigen is present on most cells of myeloid origin including granulocytes , monocytes , mast cells , and GM-progenitor cells. It is also expressed by the majority of A mL , C mL in myeloid blast crisis , and in a smaller fraction of lymphoid leukemias. It is absent from normal lymphocytes , platelets and erythrocytes. CD13 is also present on fibroblasts; endothelial cells , epithelial cells from renal proximal tubules and intestinal brush border , bone marrow stromal cells , osteoclasts , and cells lining bile duct canaliculi. CD13 is identical to aminopeptidase N (APN) , a prominent membrane-bound metalloprotease present on the surface of intestinal brush border and renal tubules. CD13 plays a role in metabolism of biologically active peptides , in phagocytosis , and in bactericidal/tumoricidal activities. It also serves as a receptor for human coronaviruses (HCV). The lineage-restricted pattern of expression of CD13 within the hemopoietic compartment suggests that it may be important in myeloid cell differentiation.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.