CD11c (Dendritic Cell Marker)(ITGAX/1242) , Biotin conjugate , 0.1mg / mL

Recognizes a protein of 145 kDa , identified as CD11c. CD11c (ITGAX) , a member of the leukointegrin family , shares the same beta subunit with other members of the leukocyte adhesion molecule family , which includes CD11a (LFA-1) , CD11b (MAC-1) and CD11d (ITGAD) , but has a unique alpha chain. CD11c has been shown to play a role in phagocytosis , cell migration , and cytokine production by monocytes/macrophages as well as induction of T-cell proliferation by Langerhans cells. CD11c is expressed prominently on the plasma membranes of monocytes , tissue macrophages , NK cells , and most dendritic cells (DCs). A lower level of expression is also observed on neutrophils as a result of its high level of expression on most DCs. An antibody to CD11c may aid in identification of lesions with histiocytic origin. It may also been used as a marker for hairy cell leukemia in paraffin-embedded tissues.