Protocadherin FAT2 (FAT Atypical Cadherin 2) (8C5) , Biotin conjugate , 0.1mg / mL

This antibody recognizes a protein of 480 kDa , which is identified as FAT2. The cadherins represent a family of Ca2 -dependent adhesion molecules that function to mediate cell-to-cell binding that is critical for the maintenance of structure and morphogenesis. Cadherins each contain a large extracellular domain at the N-terminus , which is characterized by a series of five homologous repeats , the most distal of which is thought to be responsible for binding specificity. The relatively short C-terminal intracellular domain interacts with a variety of cytoplasmic proteins , including beta-catenin , to regulate cadherin function. The cadherin superfamily includes cadherins , protocadherins , desmogleins and desmocollins. FAT2 (FAT tumor suppressor homolog 2) is a single-pass type I membrane protein that belongs to the protocadherin subfamily of cadherins. FAT2 contains one Laminin G-like domain , two EGF-like domains and 32 cadherin domains and is believed to function as a cell adhesion molecule , controlling cell proliferation and playing an important role in cerebellum development._x000D__x000D_Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors._x000D_