N-Cadherin / Cadherin-2 / CD325 (NCAD) (8C11) , Biotin conjugate , 0.1mg / mL

This antibody recognizes a protein of ~140 kDa , identified as N-Cadherin (NCAD) , also known as CD325. NCAD is a member of the Cadherin superfamily , and consists of five extracellular repeats , a transmembrane domain and a cytoplasmic domain. CD325 deficient mice die at day 10 of gestation and embryos display major heart defects and malformed neural tubes and somites. Consistent with this , CD325 has been implicated in several aspects of cardiac development including the precardiac mesoderm , establishment of left-right symmetry and cardiac looping morphogenesis. Furthermore , CD325 is normally involved in inducing cell cycle arrest and its expression is frequently deregulated in cancer cells. Studies have linked N-cadherin to cancer metastasis by showing the aggressive tumor cells had preferentially turned on N-cadherin as opposed to E- or P-cadherin._x000D__x000D_Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.