Calpain 1(CAPN1/1530) , Biotin conjugate , 0.1mg / mL

Calpain 1 is an intracellular calcium-dependent protease that cleaves cytoskeletal and sub-membranous proteins. Calpains are non-lysosomal , calcium-activated intracellular cysteine proteases. Calpains mediate specific Ca2 - dependent processes including cell fusion , mitosis and meiosis. Calpains are heterodimers of a small regulatory subunit and one of three large catalytic subunits , designated Calpain 1 , Calpain 2 and Calpain p94. Calpastatin regulates Calpain by inhibiting both the proteolytic activity of Calpain and its binding to membranes. Calpastatin exists in two types , tissue type and erythrocyte type , resulting from both alternative splicing and proteolytic processing. Calpain 1 co-localizes with human leukocyte antigen-DR (HLA-DR) on activated microglia in the aging brain. Calpain influences the process of spermatogenesis and the events preceding fertilization , such as the acrosome reaction. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.