S100B (Astrocyte and Melanoma Marker) (SH-B1) , Biotin conjugate , 0.1mg / mL

S100A and S100B proteins are two members of the S100 family of calcium binding proteins. S100A is composed of an alpha and a beta chain whereas S100B is composed of two beta chains. This antibody is specific against an epitope located on the beta-chain (i.e. in S-100A and S-100B) but not on the alpha-chain of S-100 (i.e. in S-100A and S100A0). This antibody can be used to localize S-100A and S-100B in various tissue sections. S-100 protein has been found in normal melanocytes , Langerhans cells , histiocytes , chondrocytes , lipocytes , skeletal and cardiac muscle , Schwann cells , epithelial and myoepithelial cells of the breast , salivary and sweat glands , as well as in glial cells. Neoplasms derived from these cells also express S-100 protein , albeit non-unifor mLy. A large number of well-differentiated tumors of the salivary gland , adipose and cartilaginous tissue , and Schwann cell-derived tumors express S-100 protein. Almost all malignant melanomas and cases of histiocytosis X are positive for S-100 protein.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.