Superoxide Dismutase 1 (SOD1) (Antioxidant Enzyme) (SOD1/2089) , Biotin conjugate , 0.1mg / mL

Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically , SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions , which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases , including amyotrophic lateral sclerosis (ALS) , a neurodegenerative disease characterized by the loss of spinal motor neurons , Down syndrome and Alzheimer s disease. In familial ALS , several mutations in SOD-1 predominate , resulting in the loss of zinc binding , the loss of scavenging activity of SOD-1 , and correlate with an increase in neurotoxicity and motor neuron death.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.