HSP60 (Heat Shock Protein 60) (Mitochondrial Marker)(CPTC-HSPD1-1) , Biotin conjugate , 0.1mg / mL

The heat shock proteins (HSPs) comprise a group of highly conserved , abundantly expressed proteins with diverse functions , including the assembly and sequestering of multiprotein complexes , transportation of nascent polypeptide chains across cellular membranes , and the regulation of protein folding. The mitochondrial and cytosolic localization of HSP60 , combined with its binding and catalysis of folding of newly synthesized proteins destined for the mitochondrial matrix , classify this protein as a molecular chaperone. An additional role of HSP 60 is to act as a cell surface marker for T cell recognition , as well as being involved in a danger signal cascade immune response. HSP60 has been shown to influence apoptosis in tumor cells , and changes in its expression level may serve as a biomarker , as down-regulated HSP60 expression indicates a poor prognosis as well as a risk of tumor infiltration development , especially with regard to urothelial carcinomas. In ovarian cancer , decreased expression of HSP60 correlates with aggressive tumor types , while overexpression is correlated with a better patient prognosis. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.