PDZ and LIM Domain 1(CPTC-PDLIM1-1) , Biotin conjugate , 0.1mg / mL

CLP36 , also known as PDLIM1 , CLIM1 or Elfin , is a 329 amino acid cytoplasmic protein that associates with actin stress fibers at the cytoskeleton. Expressed at high levels in skeletal muscle and heart and at lower levels in colon , small intestine , spleen , lung , placenta , kidney , liver , thymus and pancreas , CLP36 functions as a cytoskeletal protein that is thought to act as an adaptor , bringing target proteins to the cytoskeleton. Specifically , CLP36 interacts with Clik1 (-actinin-1 , thereby facilitating the association of Clik1 with actin stress fibers. CLP36 contains one PDZ domain and one LIM zinc-binding domain through which it conveys its protein-protein binding capabilities. Human CLP36 shares 88% sequence similarity with its rat counterpart , suggesting a conserved function between species. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.