CD25 / IL2RA (Activated Lymphocyte Marker)(IL2RA/2394) , Biotin conjugate , 0.1mg / mL

Recognizes a protein of 55 kDa , identified as CD25. It is expressed on activated T- and B-cells and activated monocytes/macrophages. With respect to lymphomas , CD25 is present on malignant cells of Hodgkin's disease , HTLV-1 adult T-cell leukemia , cutaneous T-cell lymphoma , and hair cell leukemia. Increased levels of soluble CD25 are observed in the leukemias/lymphomas and inflammatory/ autoimmune diseases. CD25 molecule alone appears to function as a low affinity receptor and associates with CD122 (IL-2R chain , p75) and CD132 (common chain) to form the high affinity IL-2 receptor complex. CD25 antibodies detect three epitope regions , A , B and C. This MAb recognizes the epitope B , which is located at residue 3-104 of CD25 and doe not block IL-2 binding to CD25. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.