STAT5B(STAT5B/2657) , Biotin conjugate , 0.1mg / mL

Signal transducer and activator of transcription 5A (Stat5a) and Stat5b , which share 96% homology , undergo receptor tyrosine kinase or G protein-coupled receptor-dependent phosphorylation in response to cytokines or growth factors , and then form homo- or heterodimers that translocate to the nucleus , where they initiate transcription. Activation of Stat5a via IL-2 , IL-3 , IL-7/ GM-CSF , erythropoietin , thrombopoietin and growth hormones influences proliferation , differentiation and apoptosis in lymphohematopoietic cells. Phosphorylation of Stat5a at Ser127/Ser128 and Ser779 are contigent on ErbB-4-mediated activation of Stat5a. Activation of Stat5b via IL-2 , IL-4 , CSF-1 and growth hormones influences TCR signaling , apoptosis , adult mammary gland development and sexual dimorphism of liver gene expression. Stat5b is the major liver-expressed Stat5 form that has been shown to fuse with the retinoic acid receptor a gene in acute promyelocytic leukemias (APLL). Stat5a/b null mice have severely impaired lymphoid development and differentiation. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.