Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) (TYMP/2890R) , Biotin conjugate , 0.1mg / mL

This antibody recognizes a protein (amino acid 482) of 55 kDa (in vivo 110 kDa homodimer) , identified as platelet-derived endothelial growth factor (PD-ECGF) , same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate , it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines , cytotoxic agents used in the treatment of a variety of malignancies , into active cytotoxic metabolites (e.g. 5€™-deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites_x000D_ _x000D_ Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors._x000D_