Neurofilament (NF-L) (Neuronal Marker) (NEFL/2983R) , Biotin conjugate , 0.1mg / mL

This MAb reacts with a 68 kDa protein , identified as light sub-unit of neurofilaments (NF-L). Neurofilaments make up the main structural elements of axons and dendrites and are found in neurons , peripheral nerves , and sympathetic ganglion cells. Neurofilaments consist of three major subunits with molecular weights of 68 kDa (NF-L) , 160 kDa (NF-M) and 200 kDa (NF-H). Anti-neurofilament stains a number of neural , neuroendocrine , and endocrine tumors. Neuromas , ganglioneuromas , gangliogliomas , ganglioneuroblastomas , and neuroblastomas stain positively for anti-neurofilament. Neurofilaments are also present in paragangliomas as well as adrenal and extra-adrenal pheochromocytomas. Carcinoids , neuroendocrine carcinomas of the skin , and oat cell carcinomas of the lung also express neurofilament.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.