HPV16 E1/E4 (Human Papilloma Virus 16)(HPV16 E1/E4) , Biotin conjugate , 0.1mg / mL

The human papilloma virus (HPV) family of DNA tumor viruses includes HPV16 , a 'high-risk' sexually-transmitted HPV that can lead to cervical , anal , vulvar , head , neck , and penile cancer. The HPV16E1/E4 protein is expressed abundantly in cells supporting viral DNA amplification , but is lost during malignant progression. HPV16E1/E4 causes G2 cell cycle arrest by associating with and preventing the nuclear entry of Cdk1/cyclin B1 complexes. HPV16E1/E4 also interacts with cyclin A and Cdk2 during the G2 phase of the cell cycle , and this association may increase the efficiency with which HPV16E1/E4 is able to prevent mitotic entry. HPV16E1/E4 also associates with keratin intermediate filaments and causes the network to collapse. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.