Ubiquitin (Autophagy Marker)(UBB/3143R) , Biotin conjugate , 0.1mg / mL

Ubiquitin is a highly conserved and plays an essential role in the ubiquitin-proteasome pathway. In ubiquitination process , it is first activated by forming a thiol-ester complex with the activation component E1 , which is then transferred to ubiquitin-carrier protein E2 , followed by to ubiquitin ligase E3 for final delivery to epsilon-NH2 of the target protein lysine residue. IkB , p53 , cdc25A , Bcl-2 etc. are shown as targets of ubiquitin-proteasome process as part of regulation of cell cycle progression , differentiation , cell stress response , and apoptosis. Moreover , ubiquitin have been reported to bind covalently with pathological inclusions which are resistant to degradation e. g. neurofibrillary tangles/paired helical filaments in Alzheimer's disease , Lewy bodies seen in Parkinson's disease , and Pick bodies found in Pick's disease etc. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.