MCAM (Melanoma Cell Adhesion Molecule) / MUC18 / CD146(MCAM/3179) , Biotin conjugate , 0.1mg / mL

The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein , also designated MCAM , MUC 18 or CD146 , that belongs to the immunoglobulin superfamily and functions as a Ca2 -independent cell adhesion molecule. Mel-CAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage , but not normal melanocytes. Mel-CAM is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.