Fodrin / Alpha Spectrin II (SPTAN1) / NEAS(SPTAN1/3351) , Biotin conjugate , 0.1mg / mL

Spectrin , an actin binding protein that is a major component of the cytoskeletal superstructure of the erythrocyte plasma membrane , is essential in determining the properties of the membrane including its shape and deformability. Spectrins function as membrane organizers and stabilizers , composed of nonhomologous and chains , which aggregate side-to-side in an antiparallel fashion to form dimers , tetramers , and higher polymers. Spectrin I and spectrin I are present in erythrocytes , whereas spectrin II (also designated fodrin ) and spectrin II (also designated fodrin ) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion , but spectrin dimers seem to lack this function. Activation of calpain results in the breakdown of spectrin II , a neuronal cytoskeleton protein. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.