PAI-RBP1 / SERBP1 / SERPINE1(SERBP1/3497) , Biotin conjugate , 0.1mg / mL

PAI-RBP1 (plasminogen activator inhibitor 1 RNA-binding protein) , also known as SERBP1 (SERPINE1 mRNA-binding protein 1) , CGI-55 , CHD3IP (chromodomain helicase DNA binding protein 3 interacting protein) , HABP4L or PAI-RBP1 , is a membrane-associated protein that localizes to the nucleus , the perinuclear region of the cytoplasm and the plasma membrane. PAI-RBP1 is believed to play a role in the regulation of mRNA stability , as it specifically binds to the CRS (cyclic nucleotide-responsive sequence) motif of the PAI-1 mRNA and acts to stabilize the mRNA and regulate its expression. In addition , PAI-RBP1 interacts with Mi2- and may be involved in chromatin remodeling. PAI-RBP1 also interacts with PGRMC1 and participates in the transduction of Progesterone s antiapoptotic action in ovarian cell types. The gene encoding PAI-RBP1 is overexpressed in ovarian cancer , suggesting a possible role for PAI-RBP1 in tumorigenesis and tumor metastasis. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.