Cyclin D1 (G1-Cyclin & Mantle Cell Lymphoma Marker)(CCND1/3548) , Biotin conjugate , 0.1mg / mL

Recognizes a protein of 36 kDa , identified as cyclin D1. Cyclin D1 , one of the key cell cycle regulators , is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally , hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.