CD95 / FAS / TNFRSF6(FAS/3588) , Biotin conjugate , 0.1mg / mL

This MAb specifically recognizes CD95 , also known as Fas , a transmembrane glycoprotein with a MW of 40-45 kDa , containing 8 kDa of N-glycoside-linked polysaccharide. It is a receptor for TNFSF6/FASLG , a member of the nerve growth factor receptor/tumor necrosis factor superfamily , mediating receptor-triggered apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation , which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance , in the antigen-stimulated suicide of mature T-cells , or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). CD95 antigen is expressed on the surface of various cell types , preferentially on the CD45RAlow CD45ROhigh subset of memory T lymphocytes. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.