TNF alpha(TNFA/1172) , 1mg / mL

This MAb recognizes human 17-26 kDa protein , which is identified as cytokine TNF-alpha (Tumor Necrosis Factor-alpha). TNF-alpha can be expressed as a 17 kDa free molecule , or as a 26 kDa membrane protein. TNF-alpha is a protein secreted by lipopolysaccharide-stimulated macrophages , and causes tumor necrosis when injected into tumor bearing mice. TNF alpha causes cytolysis of certain transformed cells , being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells , TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines , activating polymorphonuclear neutrophils and osteoclasts , and induction of interleukin 1 , prostaglandin E2 and collagenase production. TNF alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.This antibody is available purified with BSA/azide at 200 ug/ mL , or BSA/azide-free at 1 mg / mL.