Immortalized Human Aortic Endothelial Cells

Description Immortalized Human Aortic Endothelial Cells (IM-HAEC) have been obtained by immortalizing primary Human Aortic Endothelial Cells with Lenti‐SV40 Lentivirus. Immortalized cells were controlled passaging side by side with the primary cells. Primary cells go into senescence after the 4th passage while the SV40‐tranduced cells go beyond 30 passages. Endothelial cells constitute the natural interface between the blood and the underlying tissue. Changes in endothelial cell function appear to play a key role in the pathogenesis of atherosclerosis. Endothelial cells synthesize and secrete activators as well as inhibitors of both the coagulation system and the fibrinolysis system in addition to mediators that influence the adhesion and aggregation of blood platelets. Endothelial cells also release molecules that control cell proliferation and modulate vessel wall tone. Human aortic endothelial cells (HAEC) produce antithrombotic and thrombotic factors such as t‐PA and PAI‐1. Each vial of IM-HAEC contains more than 1 million viable cells. Cells Online also offers optimized medium and reagents for the growth of IM-HAEC which are quality tested together and guaranteed to give maximum performance as a global solution for in vitro IM-HAEC culture.