ALK (Anaplastic Lymphoma Kinase) / CD246(ALK/3218R) , 0.2mg / mL

The wild-type anaplastic lymphoma kinase (ALK) protein is a 200 kDa transmembrane receptor tyrosine kinase. Its expression is restricted to a few scattered cells in the nervous system (some glial cells and neurons , and a few endothelial cells and pericytes). ALK has been found to be rearranged , mutated , or amplified in a series of tumors. The hybrid gene , NPM-ALK , created by the t(2;5)(p23;q35) chromosomal translocation , encodes part of the nucleolar phosphoprotein nucleophosmin (NPM) , joined to the entire cytoplasmic portion of ALK. As a consequence , the ALK gene comes under the control of the NPM promoter , which induces a permanent and ubiquitous transcription of the NPM-ALK hybrid gene , resulting in the production of a 80 kDa NPM-ALK chimeric protein. This translocation is found in anaplastic large cell lymphomas (ALCL). Reportedly , expression of ALK indicates a better prognosis. Approximately 5%-10% of non-small cell lung carcinomas also express ALK protein , producing a cytoplasmic staining pattern. This MAb also reacts with blood vessels that serves as an internal positive control. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.