CD16 / Fcγ Receptor III (CB16) , 1mg / mL

This antibody recognizes CD16 (FcgammaRIII) , the low-affinity receptor for IgG with an apparent molecular weight of 50-80 kDa. CD16 is represented by two similar genes , CD16A (FcgammaRIIIA) , which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (FcgammaRIIIB) , which exist as a monomeric GPI-anchored form in neutrophils. Furthermore , there are two known polymorphisms of CD16B , NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding , both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC) , phagocytosis , degranulation and proliferation._x000D__x000D_This antibody is available purified with BSA/azide at 200 ug/ mL , or BSA/azide-free at 1 mg / mL.