CD18(68-5A5) , Biotin conjugate , 0.1mg / mL

This antibody recognizes a transmembrane glycoprotein of 95 kDa , identified as CD18 or integrin -2 (Workshop III). It complexes non-covalently with either L , M , or X integrin (CD11a , b , or c) to form the heterodimers , LFA-1 , Mac-1 , and p150 , 95 , respectively. LFA-1 is the receptor for three members of the Ig supergene family of proteins , ICAM-1 (CD54) , ICAM-2 (CD102) , and Mac-1 and p150 , 95 bind to ICAM-1 , fibrinogen , and iC3b. ICAM-3 (CD50). CD18/CD11 heterodimeric molecules are involved with cell/cell and cell/extracellular adhesion in immune and inflammatory responses. This MAb blocks these cellular interactions.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.