p27 / KIP1(SX53G8) , Biotin conjugate , 0.1mg / mL

This MAb recognizes a 27 kDa protein , identified as the p27Kip1 , a cell cycle regulatory mitotic inhibitor. It is highly specific and shows no cross-reaction with other related mitotic inhibitors. In Western blotting of cell lysates from 7 human breast cancer cell lines (ZR75-1 , ZR75-30 , MCF-7 , MDAMB453 , T47D , CAL51 , 734B) , the antibody labels a single band corresponding to p27Kip1. It functions as a negative regulator of G1 progression and has been proposed to function as a possible mediator of TGF-betanduced G1 arrest. p27Kip1 is a candidate tumor suppressor gene. Reportedly , low p27 expression has been associated with unfavorable prognosis in renal cell carcinoma , colon carcinoma , breast carcinomas , non-small-cell lung carcinoma , hepatocellular carcinoma , multiple myeloma , and lymph node metastases in papillary carcinoma of the thyroid , as well as a more aggressive phenotype in carcinoma of the cervix.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.