CD99 / MIC2 (Ewing's Sarcoma Marker)(12E7 + MIC2/877) , Biotin conjugate , 0.1mg / mL

This antibody recognizes a sialoglycoprotein of 27-32 kDa , identified as CD99 , or MIC2 gene product , or E2 antigen. MIC2 gene is located in the pseudo-autosomal region of the human X and Y chromosome. MIC2 gene encodes two distinct proteins , which are produced by alternative splicing of the CD99 gene transcript and are identified as bands of 30 and 32 kDa (p30/32).Although its function is not fully understood , CD99 is implicated in various cellular processes including homotypic aggregation of T cells , upregulation of T cell receptor and MHS molecules , apoptosis of immature thymocytes and leukocyte diapedesis. CD99 is expressed on the cell membrane of some lymphocytes , cortical thymocytes , and granulosa cells of the ovary. Most pancreatic islet cells , Sertoli cells of the testis , and some endothelial cells express this antigen. Mature granulocytes express very little or no CD99. MIC2 is strongly expressed on Ewing's sarcoma cells and primitive peripheral neuroectodermal tumors.