CD21(FR5A10) , Biotin conjugate , 0.1mg / mL

Recognizes a protein of 140 kDa , which is identified as the complement receptor 2 (CR2)/CD21. Its epitope is located in 5-8 short consensus repeats (SCRs). This MAb is highly specific to CR2 and shows no cross-reaction with CR1. This protein is expressed strongly on mature B cells , follicular dendritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny , CD21 appears after the pre-B-stage , is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro. CD21 functions as receptor for C3d , C3dg and iC3b Complement components , for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19 , CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation. MAb FR5A10 can be used for EBV receptor studies , interactions between B and T cells especially through CD23 , human complement receptor (CR2) studies and IFN-alpha receptor studies.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.