MA mL3 (Mastermind Like Transcriptional Coactivator 3) (MA mL3/1303) , Biotin conjugate , 0.1mg / mL

MA mL3 (mastermind-like protein 3) is a nuclear speckle protein that acts as a transcriptional coactivator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MA mL3 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region , MA mL3 interacts with the ankyrin repeats of the Notch proteins Notch 1 , Notch 2 , Notch 3 and Notch 4.This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-J , a complex that can then induce HES1 gene expression. While the N-terminal domain of MA mL3 is essential for proper Notch binding , the C-terminal domain of MA mL3 is essential for transcriptional activation. Due to its involvement in cell signaling and transcriptional activation , upregulation of MA mL3 is thought to be involved in oncogenesis.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.