TIMP1 (Marker of Lymph Node Metastasis)(2A5) , Biotin conjugate , 0.1mg / mL

TIMP-1 , TIMP-2 , TIMP-3 and TIMP-4 (for tissue inhibitor of metalloproteinases -1 , -2 , -3 and -4) complex with metalloproteinases such as collagenases , gelatinases and stromelysins , resulting in irreversible inactivation of the metalloproteinase. TIMP-1 is identical to EPA (erythroid-potentiation activity). PTH has been shown to be a regulator of TIMP-2 in osteoblastic cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia , and in the formation , branching and expansion of epithelial tubes. TIMP-4 is most highly expressed in heart tissues. Studies have demonstrated that TIMP1 is useful as a biomarker for early detection of colorectal cancer , outperforming CEA. Additionally , TIMP1 studies have demonstrated its role in CRC tumorigenesis , as well as observing its overexpression in metastatic lymph nodes. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.