CD73 (Immuno-Oncology Target)(NT5E/2545) , Biotin conjugate , 0.1mg / mL

CD73 (also designated ecto-5'-nucleotidase , E5NT , NT , NT5 , NTE , eN and eNT) is a glycosyl-phosphatidylinositol (GPI)-anchored adhesion protein that catalyzes the dephosphorylation of extracellular purine and pyrimidine nucleotides to their corresponding bioactive nucleosides. CD73 is a dimer of two identical subunits that depends on GPI to link with the external face of the plasma membrane. Similar to other GPI-anchored proteins , CD73 mediates co-stimulatory signals in T cell activation. CD73 has few structural variants , yet elicits diverse biological function through differential regulation in endothelial cells (EC) , subpopulations of B and T cells , germinal center follicular dendritic cells and on thymic medullary reticular fibroblasts. For example , IgG mediated neutralization of CD73 interferes with lymphocyte adhesion to EC , and blocks aggregation of germinal center B cells and follicular dendritic cells. Furthermore , IgG-mediated targeting of lymphocyte CD73 , but not of endothelial cell CD73 , causes shedding of CD73 and tyrosine phosphorylation of proteins. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.