ATRX / RAD54 (Alpha Thalassemia Mental Retardation) (ATRX/2900R) , Biotin conjugate , 0.1mg / mL

ATRX is a member of the Snf2 family of helicase/ATPases , which contribute to the remodeling of the nucelosome structure in an ATP-dependent manner , and facilitate the initiation of transcription and replication. Structurally , ATRX contains a PHD zinc finger motif. ATRX is regulated throughout the cell cycle where it is differentially distributed within the nucleus. During interphase , ATRX predominately associates with the nuclear matrix , while during mitosis , ATRX localizes with condensed chromatin. At the onset of M phase , phosphorylation rapidly induces this redistribution of ATRX to the short arms of human acrocentric chromosomes , where it then specifically complexes with heterochromatin protein 1 alpha to mediate chromosomal segregation. Mutations in the ATRX gene correlate with a high incidence of severe X-linked form of syndromal mental retardation associated with alpha-thalassemia or ATRX syndrome. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.