Transferrin (Early Marker of Oligodendrocytes)(TF/3001) , Biotin conjugate , 0.1mg / mL

Iron (Fe) is a tightly metabolically controlled mineral and growth factor present in all living cells. Iron not bound in erythrocyte hemoglobin is transported by transferrin (Tf) , the iron transport protein of vertebrate serum. The transferrin protein contains two homologous domains , each of which contain an Fe-binding site. The majority of transferrin is synthesized in the liver and secreted into the blood , but it is also produced in lower amounts in testis and brain as well as in oligodendrocytes , where transferrin is an early marker of oligodendrocyte differentiation. From the blood , transferrin is internalized by erythroblasts and reticulocytes upon binding the transferrin receptor (TfR) , also designated CD71 , through a system of coated pits and vesicles. After Fe release , transferrin is returned to the extracellular medium , where it can be reused. Defects in the transferrin gene results in atransferrinemia , a rare autosomal recessive disorder characterized by microcytic anemia and iron loading. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.