TIGIT / VSTM3 / VSIG9 (Immune Checkpoint for Cancer)(TIGIT/3106) , Biotin conjugate , 0.1mg / mL

TIGIT is a checkpoint inhibitor which binds with high affinity to the poliovirus receptor (PVR) , causing increased IL10 secretion , decreased IL12B secretion. TIGIT binding to PVR also causes the suppression of T cell activation by promoting the generation of mature immuno-regulatory dendritic cells. It is expressed at low levels on natural killer (NK) cells , as well as peripheral memory and regulatory CD4 T cells. At the protein level , it is upregulated following the activation of these cells. Functionally , TIGIT is similar to CTLA4. The ligands for TIGIT include CD155 (signal abrogation) and CD226 (signal stimulation). It has been demonstrated to be upregulated on T cells in many cancers and is a immuno-oncology target for therapy. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.