CD262 / DR5(DR5/3381) , Biotin conjugate , 0.1mg / mL

Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated by two distinct cell surface receptors , designated TNF-R1 and TNF-R2 , which are expressed on most cell types. TNF function is primarily mediated through TNF-R1 signaling. Both receptors belong to the growing TNF receptor superfamily which includes Fas antigen and CD40. TNF-R1 contains a cytoplasmic motif , termed the death domain , that has been found to be necessary for the transduction of the apoptotic signal. The death domain is also found in several other receptors , including Fas , DR2 (or TRUNDD) , DR3 (death receptor 3) , DR4 and DR5. TRUNDD , DR4 and DR5 are receptors for the apoptosis-inducing cytokine TRAIL. A non-death domain-containing receptor , designated decoy receptor (DcR1 or TRID) , also specifically associates with TRAIL and may play a role in cellular resistance to apoptotic stimuli. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.