Volume : 50 µL
Clone Number :
Aliases : ATF5 antibody; ATFXCyclic AMP-dependent transcription factor ATF-5 antibody; cAMP-dependent transcription factor ATF-5 antibody; Activating transcription factor 5 antibody; Transcription factor ATFx antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9Y2D1
Immunogen : Recombinant Human Cyclic AMP-dependent transcription factor ATF-5 protein (1-282AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Transcription factor that either stim µLates or represses gene transcription thro µgh binding of different DNA reg µLatory elements such as cAMP response element (CRE) (consensus : 5\'-GTGACGT[AC][AG]-3\'), ATF5-specific response element (ARE) (consensus : 5\'-C[CT]TCT[CT]CCTT[AT]-3\') but also the amino acid response element (AARE), present in many viral and cell µLar promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation (PubMed : 10373550, PubMed : 15358120, PubMed : 21212266, PubMed : 20654631). Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4 (PubMed : 15358120). Important reg µLator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons. Must be down-reg µLated in order for such cells to exit the cycle and differentiate (By similarity). Participates in the pathways by which SHH promotes cerebellar gran µLe neuron progenitor cells proliferation (By similarity). Critical for survival of mature olfactory sensory neurons (OSN), directs expression of OSN-specific genes (By similarity). May be involved in osteogenic differentiation (PubMed : 22442021). Promotes cell proliferation and survival by inducing the expression of EGR1 sinergistically with ELK1. Once acetylated by EP300, binds to ARE sequences on target genes promoters, such as BCL2 and EGR1 (PubMed : 21791614). Plays an anti-apoptotic role thro µgh the transcriptional reg µLation of BCL2, this function seems to be cell type-dependent (By similarity). Cooperates with NR1I3/CAR in the transcriptional activation of CYP2B6 in liver (PubMed : 18332083). In hepatic cells, represses CRE-dependent transcription and inhibits proliferation by blocking at G2/M phase (PubMed : 22528486, PubMed : 18701499). May act as a negative reg µLator of IL1B transduction pathway in liver (PubMed : 24379400). Upon IL1B stim µLus, cooperates with NLK to activate the transactivation activity of C/EBP subfamily members (PubMed : 25512613). Besides its function of transcription factor, acts as a cofactor of CEBPB to activate CEBPA and promote adipocyte differentiation (PubMed : 24216764). Reg µLates centrosome dynamics in a cell-cycle- and centriole-age-dependent manner. Forms 9-foci symmetrical ring scaffold around the mother centriole to control centrosome function and the interaction between centrioles and pericentriolar material (PubMed : 26213385).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : Antigen Affinity Purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : ATF5
Research Areas : Epigenetics and Nuclear Signaling
Complex Carbohydrates
Multivalent Biotinylated Polymers
Univalent Biotinylated Probes
Multivalent Fluoresceinated Polymers
Multivalent Polymers and Sets
Sets of Carbohydrate Polymers
Glycoamino Acids
Sialic Acid Derivatives
