DNA pol β (Acetyl Lys72) rabbit pAb - 50 μL

Catalytic activity: Deoxynucleoside triphosphate + DNA (n) = diphosphate + DNA (n+1). Cofactor: Binds 2 magnesium ions per subunit. Domain: Residues 239-252 form a flexible loop which appears to affect the polymerase fidelity. function: Repair polymerase. Conducts "gap-filling" DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. PTM: Methylation by PRMT6 stimulates the polymerase activity by enhancing DNA binding and processivity. similarity: Belongs to the DNA polymerase type-X family. subunit: Monomer.