pMEVHA-P38G-K56M

Human P38γ (MAPK12) Xpress Clones Mitogen-activated protein kinases (MAPKs) cascade relays extracellular signals from cell membrane to the nucleus to induce intracellular responses and to regulate many aspects of cell physiology. These cascades, including JNK, ERK and p38 pathways, consist of distinct members of regulatory enzymes that serially activate one another in response to growth factors, cytokines and other mitogenic stimuli, and lead to activation or inactivation of transcription factors. Proinflammatory cytokine and microbial products activate p38 (SAPK2, MAPK12) gene regulating pathway and cause the expression of multiple cytokine genes including IL-1, IL-6 and TNF alpha. There're four known p38 isoforms (α, β, γ and δ) that share about 60% homology. Gene Name: Homo sapiens mitogen-activated protein kinase 12 (MAPK12), (Nicknames: p38 gamma, p38r, p38g) - 20 ug