IgG1 rabbit pAb - 50 μL

Disease: Chromosomal aberrations involving IGHG1 may be a cause of multiple myeloma [MIM: 254500]. Translocation t (11;14) (q13;q32) with CCND1; translocation t (4;14) (p16. 3;q32. 3) with FGFR3; translocation t (6;14) (p25;q32) with IRF4. miscellaneous: Disease protein OMM may represent an allelic form or another gamma chain subclass. miscellaneous: Disease protein WIS is lacking most of the V region and all of the CH1 region. miscellaneous: Disease protein ZUC lack most of the V region, all of the CH1 region, and part of the hinge compared with normal gamma-3 heavy chains. miscellaneous: EU also differs in the amidation states of residues 155, 166, 177, 195, 198, 269, and 272 and in the order of residues 268-272. miscellaneous: KOL also differs in the amidation states of residues 198, 267 and 272. miscellaneous: Nie also differs in the amidation states of 35, 116, 198, 269 and 272. miscellaneous: Nie has the G1M (17) allotypic marker, 97-K, and the G1M (1) markers, 239-D and 241-L. KOL and EU sequences have the G1M (3) marker and the G1M (non-1) markers. miscellaneous: The hinge region in gamma-3 chains is about four times as long as in other gamma chains and contains three identical 15-residue segments preceded by a similar 17-residue segment (12-28). online information: IGHM mutation db, polymorphism: All 4 combinations of the S/G and V/G polymorphisms at positions 191 and 216 have been observed in human mu chains. subcellular location: During differentiation, B-lymphocytes switch from expression of membrane-bound IgM to secretion of IgM. subunit: Dimer linked by 12 disulfide bonds; it has an extra interchain disulfide bond at position 7 in addition to the 11 normally present in the hinge region.