Ksr2 rabbit pAb - 50 μL

Domain: The protein kinase domain is predicted to be catalytically inactive. function: Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. PTM: Phosphorylated on Ser-474 by MARK3. similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. similarity: Contains 1 phorbol-ester/DAG-type zinc finger. similarity: Contains 1 protein kinase domain. subunit: Interacts with MAP2K1, MAP3K8, MAPK, RAS and RAF. tissue specificity: Mainly expressed in brain and kidney.