NFE2 rabbit pAb - 50 μL

Function: Required for activity at the locus control region (LCR) upstream of the globin gene complexes. Requires p18 NF-E2 for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production: globin synthesis, heme synthesis, and the procurement of iron. similarity: Belongs to the bZIP family. similarity: Belongs to the bZIP family. CNC subfamily. similarity: Contains 1 bZIP domain. subunit: Interacts with MLL2; leading to activate transcription of the beta-globin locus (By similarity). Heterodimer of p45 NF-E2 and p18 NF-E2. Forms high affinity heterodimer with MAFG; the interaction promotes erythropoiesis. tissue specificity: Expressed in hematopoietic cells and also in colon and testis.