Volume : 50 µg
Clone Number :
Aliases : CD309 antibody; CD309 antigen antibody; EC 2.7.10.1 antibody; Fetal liver kinase 1 antibody; FLK-1 antibody; FLK1 antibody; FLK1 mouse, homolog of antibody; Kdr antibody; Kinase insert domain receptor (a type III receptor tyrosine kinase) antibody; Kinase insert domain receptor antibody; KRD1 antibody; Ly73 antibody; Protein tyrosine kinase receptor FLK1 antibody; Protein-tyrosine kinase receptor flk-1 antibody; soluble VEGFR2 antibody; Tyrosine kinase growth factor receptor antibody; Vasc µLar endothelial growth factor receptor 2 antibody; VEGFR 2 antibody; VEGFR antibody; VEGFR-2 antibody; VEGFR2 antibody; VGFR2_HUMAN antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P35968
Immunogen : Recombinant Human Vasc µLar endothelial growth factor receptor 2 protein (20-764AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the reg µLation of angiogenesis, vasc µLar development, vasc µLar permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative reg µLator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Mod µLates FLT1 and FLT4 signaling by forming heterodimers. Binding of vasc µLar growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cell µLar signaling molec µLes diacylglycerol and inositol 14,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1 the reg µLatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molec µLe nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1 NOS3, PIK3R1 PTK2/FAK1 and SRC.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : KDR
Research Areas : Cancer; Cardiovasc µLar; Metabolism; Microbiology; Signal transduction; Stem cells