Volume : 50 µg
Clone Number :
Aliases : ELAV (embryonic lethal abnormal vision Drosophila) like 1 antibody; ELAV (embryonic lethal; abnormal vision; Drosophila) like 1 (Hu antigen R) antibody; ELAV like 1 antibody; ELAV like RNA binding protein 1 antibody; ELAV-like protein 1 antibody; ELAV1 antibody; ELAV1_HUMAN antibody; Elavl1 antibody; Embryonic lethal abnormal vision drosophila homolog like 1 antibody; Hu Antigen R antibody; Hu-antigen R antibody; Hua antibody; HuR antibody; MelG antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q15717
Immunogen : Recombinant Human ELAV-like protein 1 protein (2-326AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : RNA-binding protein that binds to the 3\\\'-UTR region of mRNAs and increases their stability (PubMed : 14517288, PubMed : 18285462). Involved in embryonic stem cells (ESCs) differentiation : preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3\\\'-UTR of target mRNAs (PubMed : 8626503, PubMed : 17632515, PubMed : 18285462, PubMed : 23519412, PubMed : 14731398). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5\\\'-UUUU[AG]UUU-3\\\' motif in vitro (PubMed : 8626503). With ZNF385A, binds the 3\\\'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may reg µLate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3\\\' UTR (PubMed : 29180010).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : ELAVL1
Research Areas : Epigenetics and Nuclear Signaling