Volume : 50 µg
Clone Number :
Aliases : cytokine receptor antibody; EBI3 antibody; EBV induced gene 3 protein antibody; EBV-induced gene 3 protein antibody; Epstein Barr virus induced 3 antibody; Epstein Barr virus induced gene 3 antibody; Epstein Barr virus induced gene 3 protein antibody; Epstein-Barr virus-induced gene 3 protein antibody; IL 27 subunit beta antibody; IL 27B antibody; IL-27 subunit beta antibody; IL-27B antibody; IL27 subunit antibody; IL27 subunit beta antibody; IL27B antibody; IL27B_HUMAN antibody; IL35 subunit antibody; interleukin 27 subunit beta antibody; Interleukin-27 subunit beta antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q14213
Immunogen : Recombinant Human Interleukin-27 subunit beta protein (21-227AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can reg µLate T-helper cell development, suppress T-cell proliferation, stim µLate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : EBI3
Research Areas : Cancer; Immunology