Volume : 50 µg
Clone Number :
Aliases : ADABP antibody; ADCP-2 antibody; ADCP2 antibody; Adenosine deaminase complexing protein 2 antibody; CD26 antibody; Dipeptidyl peptidase 4 antibody; Dipeptidyl peptidase 4 soluble form antibody; Dipeptidyl peptidase IV antibody; Dipeptidyl peptidase IV membrane form antibody; Dipeptidyl peptidase IV soluble form antibody; DPP IV antibody; DPP4 antibody; DPP4_HUMAN antibody; DPPIV antibody; T-cell activation antigen CD26 antibody; TP103 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P27487
Immunogen : Recombinant Human Dipeptidyl peptidase 4 protein (473-588AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Cell surface glycoprotein receptor involved in the costim µLatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive reg µLator of T-cell coactivation, by binding at least ADA, CAV1 IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also reg µLates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericell µLar proteolysis of the extracell µLar matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that reg µLates various physiological processes by cleaving peptides in the circ µLation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the pen µLtimate residue is proline.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DPP4
Research Areas : Cancer; Cell biology; Immunology; Metabolism; Stem cells