CD33(C33/69) , Biotin conjugate , 0.1mg / mL

Recognizes a 67 kDa glycoprotein , which is identified as CD33. It is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage , binds sialic acid residues in N- and O-glycans on cell surfaces , and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors , monocytes , granulocytes , dendritic cells and mast cells. It is absent on platelets , lymphocytes , erythrocytes and hematopoietic stem cells.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.