CD36(185-1G2) , Biotin conjugate , 0.1mg / mL

Recognizes a protein of 80 kDa-90 kDa , identified as CD36 (Workshop IV; Code P-26). Its epitope maps between aa155-183. It is expressed on platelets , monocytes and macrophages , microvascular endothelial cells , erythrocyte precursors , mammary epithelial cells , and some macrophage derived dendritic cells. CD36 acts as a receptor for thrombospondin (TSP) , collagen types I , IV and V , P. falciparum malaria-infected erythrocytes , and sickle erythrocytes. It also functions as a scavenger receptor , mediating macrophage uptake of oxidized low-density lipoprotein (LDL) and recognition of apoptotic polymorphonuclear leukocytes (PMN). CD36 plays a role in platelet aggregation , macrophage foam cell development , inflammation , and the tissue ischemia observed in sickle cell disease and cerebral malaria. Note that 1-4% of Japanese and East Asia population lack CD36. This MAb blocks adhesion of P. falciparum parasitized red blood cells to CD36 and strongly inhibits collagen-induced platelet aggregation.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.